Alzheimers disease ad is characterized by cognitive impairment progressive neurodegeneration and formation of amyloid a containing plaques and neurofibrillary tangles composed of hyperphosphorylated tau the neurodegenerative process in ad is initially characterized by synaptic damage accompanied by neuronal loss. Amyloid peptides prevent camkii from participating in this process of synaptic plasticity and this blockage eventually leads to the disappearance of the synapse this discovery could find an application in early phases of alzheimers disease when initial cognitive deficiencies are observed which could be linked to this synaptic malfunction. Synaptic plasticity and the mechanism of alzheimers disease by dennis j selkoe 9783540763291 available at book depository with free delivery worldwide. Abstract despite considerable progress in defining the role of the amyloid protein a in the pathogenesis of alzheimers disease ad the mechanism by which accumulation of a causes dementia remains elusive memory loss is probably caused by an a induced change in synaptic plasticity. Get this from a library synaptic plasticity and the mechanism of alzheimers disease dennis j selkoe antoine triller yves christen fondation ipsen pour la recherche thrapeutique remarkable progress has been made in alzheimers research over the last decade our understanding of which molecular mechanisms are involved in the cascade of events characteristic of the disease is
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